反应详情

A solution of 1-(2-Hydroxy-3-nitrophenyl)ethanone 1 (788 mg, 4.4 mmol), 2-(trifluoromethyl)benzaldehyde 8 (1.1 g, 6.5 mmol) and 25% aq KOH (90 mL) in EtOH (90 mL) was stirred for 12 h at room temperature. The reaction mixture was poured into ice-water and the pH was adjusted to 2 using conc. HCl. The resulting precipitate was collected by filtration, rinsed with H2O and dried under vacuum to give 9 as a yellow solid (1.4 g, 95% yield).

1. filtrationThe resulting precipitate was collected by filtration
2. washrinsed with H2O
3. customdried under vacuum