反应详情

A mixture of (E)-2-hydroxy-3-(3-(3-(trifluoromethyl)phenyl)acryloyl)benzoic acid 34 (0.8 g, 2.4 mmol), SeO2 (0.79 g, 7.1 mmol) and DMSO (5 mL) in dioxane (150 mL) was heated at reflux for 1 h. The black solid was filtered and the dioxane was evaporated. The remaining oil was suspended in H2O, filtered and dried to give 35 (0.56 g, 76% yield).

1. temperaturewas heated
2. temperatureat reflux for 1 h
3. filtrationThe black solid was filtered
4. customthe dioxane was evaporated
5. filtrationfiltered
6. customdried