Dimethyl Sulfoxide → 4-oxo-2-(3-(trifluoromethyl)phenyl)-4H-chromene-8-carboxylic acid

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Reaction Steps

A mixture of (E)-2-hydroxy-3-(3-(3-(trifluoromethyl)phenyl)acryloyl)benzoic acid 34 (0.8 g, 2.4 mmol), SeO2 (0.79 g, 7.1 mmol) and DMSO (5 mL) in dioxane (150 mL) was heated at reflux for 1 h. The black solid was filtered and the dioxane was evaporated. The remaining oil was suspended in H2O, filtered and dried to give 35 (0.56 g, 76% yield).

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