反应详情

Pyridine-4-carbonyl chloride 42 (705 mg, 5 mmol) was added to a solution of methyl 3-acetyl-2-hydroxybenzoate 38 (650 mg, 3.6 mmol) and DIEA (932 mg, 7.2 mmol) in CH3CN (10 mL). The reaction mixture was stirred at room temperature for 12 h, poured into H2O (20 mL) and extracted with CH2Cl2. The combined organic extracts were dried (MgSO4) and concentrated. The residue was purified by prep HPLC to give the product as a yellow solid (855 mg, 83% yield).

1. extractionextracted with CH2Cl2
2. dry with materialThe combined organic extracts were dried (MgSO4)
3. concentrationconcentrated
4. customThe residue was purified by prep HPLC