反应详情

To a solution of tert-butyl 6-(pyrrolidin-1-ylmethyl)pyridin-2-ylcarbamate 82 (750 mg, 2.71 mmol) in dichloromethane (10 mL) was added trifluoroacetic acid (4.0 mL) at room temperature. The resulting reaction mixture was stirred at room temperature for 6 h and then concentrated under reduced pressure. Saturated aqueous Na2CO3 was added to the resulting residue until the solution pH reached 9. The mixture was then extracted with ethyl acetate (3×25 mL). The combined organic layers were dried with Na2SO4 and concentrated under reduced pressure to afford 49 (440 mg, 92% yield).

1. customThe resulting reaction mixture
2. concentrationconcentrated under reduced pressure
3. additionSaturated aqueous Na2CO3 was added to the resulting residue until the solution pH
4. extractionThe mixture was then extracted with ethyl acetate (3×25 mL)
5. dry with materialThe combined organic layers were dried with Na2SO4
6. concentrationconcentrated under reduced pressure