反应详情

To a solution of compound 9-4 (70 mg) in AcOH—H2O (2 mL-0.1 mL), was added electrolytic iron powder (95.3 mg). The reaction mixture was stirred at room temperature for 1 hour then at 40° C. for 2 hours to complete the reaction. The reaction mixture was filtered with Celite® pad to remove iron powder. The filtrate was concentrated in vacuo. The resulting residue was purified by amino-silica gel flash column chromatography (eluent: CH2Cl2/MeOH=98/2-95/5) to obtain compound 9-5 (30 mg) as a colorless amorphous solid.

1. waitat 40° C. for 2 hours to complete
2. customthe reaction
3. filtrationThe reaction mixture was filtered with Celite® pad
4. customto remove iron powder
5. concentrationThe filtrate was concentrated in vacuo
6. customThe resulting residue was purified by amino-silica gel flash column chromatography (eluent: CH2Cl2/MeOH=98/2-95/5)