反应详情

To a solution of compound 26-5 (70 mg) in DMF-pyridine (2 mL-2 mL), was added mesyl chloride (16.3 microL). The reaction mixture was stirred at room temperature overnight. The mixture was diluted with water then it was extracted with EtOAc. The extract was washed with water, 1N HCl and brine. The organic layer was dried with anhyd. Na2SO4 and the solvent was removed under reduced pressure to obtain compound 28-1 (30 mg) as a pale yellow amorphous solid.

1. extractionit was extracted with EtOAc
2. washThe extract was washed with water, 1N HCl and brine
3. customThe organic layer was dried with anhyd
4. customNa2SO4 and the solvent was removed under reduced pressure