Methanesulfonyl chloride → (2R)-N-(4-cyanophenyl)-2-hydroxy-2-[(2R)-4-[4-(methanesulfonamido)phenyl]-3-oxo morpholin-2-yl]acetamide

Participants

Reaction Steps

To a solution of compound 26-5 (70 mg) in DMF-pyridine (2 mL-2 mL), was added mesyl chloride (16.3 microL). The reaction mixture was stirred at room temperature overnight. The mixture was diluted with water then it was extracted with EtOAc. The extract was washed with water, 1N HCl and brine. The organic layer was dried with anhyd. Na2SO4 and the solvent was removed under reduced pressure to obtain compound 28-1 (30 mg) as a pale yellow amorphous solid.

Provenance & Evidence