HCID 67222305, compound → HCID 58181897, compound

HRID 876577Notes

Reaction equation

HRID 876577 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][C:4]=1[CH2:12][N:13]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])#[N:2]>CO.C1COCC1.[Pd]>[NH2:9][C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[C:4]([CH2:12][N:13]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:17])[CH3:18])[CH:5]=1

Participants

4

Reactant 1

HCID 67222305HCID 67222305, compound

Product 1

HCID 58181897HCID 58181897, compoundYield 97.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

To a solution of compound 39-1 (0.3 g) in MeOH-THF (3 mL-3 mL), was added 10% Pd/C (30 mg). The reaction mixture was stirred under hydrogen atmosphere for 3 hours at room temperature. Then the reaction mixture was filtered with Celite® pad to remove catalyst. The filtrate was concentrated in vacuo to obtain compound 39-2 (0.27 g) as pale brown oil.

Workup

  1. filtrationThen the reaction mixture was filtered with Celite® pad
  2. customto remove catalyst
  3. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-1abb17ad1e6b47ab9540db3775b419d7
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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