HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → tert-butyl N-[[5-[[(2R)-2-[(2R)-4-(4-acetamidophenyl)-3-oxomorpholin-2-yl]-2-hydroxyacetyl]amino]-2-cyanophenyl]methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | tert-butyl N-[[5-[[(2R,3R)-4-[4-acetamido-N-(2-chloroethyl)anilino]-2,3-dihydroxy-4-oxobutanoyl]amino]-2-cyanophenyl]methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate | HCID 67222317 | — |
| Solvent | DMSO t-BuOH | HCID 86634320 | — |
| Product | tert-butyl N-[[5-[[(2R)-2-[(2R)-4-(4-acetamidophenyl)-3-oxomorpholin-2-yl]-2-hydroxyacetyl]amino]-2-cyanophenyl]methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate | HCID 67222637 | 35.9% |
Reaction Steps
According to the Step 7-5 in synthetic method for EXAMPLE 7, compound 39-4 (4.3 g) and DMF were used instead of 7-4 and t-BuOH-DMSO to obtain compound 39-5 (1.46 g) as a colorless amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987242B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-f90c7cd753b942e0919200d7b6e1c2d3 |
| Source note | uspto-grants-2015_03 |