HRID876578

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6228

N,N-Dimethylformamide

C3H7NO

结构：CC(=O)Nc1ccc(N(CCCl)C(=O)[C@H](O)[C@@H](O)C(=O)Nc2ccc(C#N)c(CN(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c2)cc1

HCID67222317

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Nc1ccc(N2CCO[C@H]([C@@H](O)C(=O)Nc3ccc(C#N)c(CN(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c3)C2=O)cc1

HCID67222637

未命名化合物

收率 35.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID86634320

未命名化合物

PROCEDURE

实验过程

According to the Step 7-5 in synthetic method for EXAMPLE 7, compound 39-4 (4.3 g) and DMF were used instead of 7-4 and t-BuOH-DMSO to obtain compound 39-5 (1.46 g) as a colorless amorphous solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f90c7cd753b942e0919200d7b6e1c2d3
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08987242B2
来源说明: uspto-grants-2015_03

反应 SMILES

[C:1]([NH:4][C:5]1[CH:47]=[CH:46][C:8]([N:9]([C:13](=[O:45])[C@H:14]([OH:44])[C@@H:15]([OH:43])[C:16]([NH:18][C:19]2[CH:20]=[CH:21][C:22]([C:41]#[N:42])=[C:23]([CH2:25][N:26]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30])[CH:24]=2)=[O:17])[CH2:10][CH2:11]Cl)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].CN(C=O)C>CC(O)(C)C.CS(C)=O>[C:1]([NH:4][C:5]1[CH:47]=[CH:46][C:8]([N:9]2[CH2:10][CH2:11][O:44][C@H:14]([C@@H:15]([OH:43])[C:16]([NH:18][C:19]3[CH:20]=[CH:21][C:22]([C:41]#[N:42])=[C:23]([CH2:25][N:26]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30])[CH:24]=3)=[O:17])[C:13]2=[O:45])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]