HCID 58717298, compound → HCID 136337786, compound

HRID 876581Notes

Reaction equation

HRID 876581 reaction equation
[OH:1][C@H:2]([C@H:6]1[O:11][CH2:10][CH2:9][N:8]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=2)[C:7]1=[O:23])[C:3]([OH:5])=O.[NH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]2[NH:32][O:33][C:34](=[O:36])[N:35]=2)=[CH:27][CH:26]=1.NC1C=C2C(=CC=1)C(N(C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)=NC=C2>CN(C=O)C>[OH:1][C@H:2]([C@H:6]1[O:11][CH2:10][CH2:9][N:8]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=2)[C:7]1=[O:23])[C:3]([NH:24][C:25]1[CH:26]=[CH:27][C:28]([C:31]2[NH:35][C:34](=[O:36])[O:33][N:32]=2)=[CH:29][CH:30]=1)=[O:5]

Participants

5

Reactant 3

HCID 58717298HCID 58717298, compoundHCID 67223591HCID 67223591, compoundHCID 178507458HCID 178507458, compound

Product 1

HCID 136337786HCID 136337786, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

According to the Step 1-3 in synthetic method for EXAMPLE 1, compound 55-6 (0.3 g) and 3-(4-aminophenyl)-1,2,4-oxadiazol-5(2H)-one with DMF were used instead of 1-2 and 6-amino-1-bis(tert-butoxycarbonyl)aminoisoquinoline to obtain compound 56-1 (26 mg) as a colorless amorphous solid.

Sources & evidence

ORD record
ord-6e612ddc94c64380aa7661a7e713ea4c
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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