HRID876581

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1nccc2cc(N)ccc12

HCID58717298

未命名化合物

结构：O=C(O)[C@H](O)[C@H]1OCCN(c2ccc(OC(F)(F)F)cc2)C1=O

HCID67223591

未命名化合物

HCID178507458

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccc(-c2noc(=O)[nH]2)cc1)[C@H](O)[C@H]1OCCN(c2ccc(OC(F)(F)F)cc2)C1=O

HCID136337786

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

According to the Step 1-3 in synthetic method for EXAMPLE 1, compound 55-6 (0.3 g) and 3-(4-aminophenyl)-1,2,4-oxadiazol-5(2H)-one with DMF were used instead of 1-2 and 6-amino-1-bis(tert-butoxycarbonyl)aminoisoquinoline to obtain compound 56-1 (26 mg) as a colorless amorphous solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6e612ddc94c64380aa7661a7e713ea4c
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08987242B2
来源说明: uspto-grants-2015_03

反应 SMILES

[OH:1][C@H:2]([C@H:6]1[O:11][CH2:10][CH2:9][N:8]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=2)[C:7]1=[O:23])[C:3]([OH:5])=O.[NH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]2[NH:32][O:33][C:34](=[O:36])[N:35]=2)=[CH:27][CH:26]=1.NC1C=C2C(=CC=1)C(N(C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)=NC=C2>CN(C=O)C>[OH:1][C@H:2]([C@H:6]1[O:11][CH2:10][CH2:9][N:8]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=2)[C:7]1=[O:23])[C:3]([NH:24][C:25]1[CH:26]=[CH:27][C:28]([C:31]2[NH:35][C:34](=[O:36])[O:33][N:32]=2)=[CH:29][CH:30]=1)=[O:5]