HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-3-fluorobenzonitrile → HCID 67222178, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-3-fluorobenzonitrile | HCID 2756431 | — |
| Reactant | tert-butyl N-(6-aminoisoquinolin-1-yl)-N-[(tert-butoxy)carbonyl]carbamate | HCID 58717298 | — |
| Reactant | HCID 67032827 | HCID 67032827 | — |
| Product | HCID 67222178 | HCID 67222178 | — |
Reaction Steps
According to the Step 1-3 in synthetic method for EXAMPLE 1, a cyclic carbonate analogue (0.2 g) derived from compound 52-4 and 4-amino-3-fluorobenzonitrile (81.7 mg) were used instead of 1-2 and 6-amino-1-bis(tert-butoxy carbonyl)aminoisoquinoline, under high concentration condition (1M), to obtain compound 67-1 (130 mg) as a colorless amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987242B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-4bd52831e94d454aa96ca186c46a2575 |
| Source note | uspto-grants-2015_03 |