反应详情

To a solution of compound 70-3 (85 mg) in CH2Cl2 (2.5 mL) at 0° C. was added TFA (0.5 mL) dropwise. The mixture was stirred for 1 h at 0° C. and at rt for 30 min whereupon an additional portion of TFA (0.5 mL) was added. After an additional 1 h at rt, the mixture was diluted with CH2Cl2 and concentrated to dryness under reduced pressure. The crude mixture was redissolved in CH2Cl2 and concentrated and this protocol was repeated 5 times with to afford compound 70-4 (65 mg) as a light semisolid. LC-MS: M+H=363. This material was used without further purification.

1. additionwas added
2. concentrationconcentrated to dryness under reduced pressure
3. dissolutionThe crude mixture was redissolved in CH2Cl2
4. concentrationconcentrated