HRID876595

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2756371

tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate

C14H20N2O2

结构：CC(=O)O[C@@H](C(=O)O)[C@H]1OCCN(c2ccc3c(c2)C(=O)N(C)C3)C1=O

HCID58181678

未命名化合物

PRODUCTS

生成物

结构：CC(=O)O[C@@H](C(=O)Nc1ccc2c(c1)CCN(C(=O)OC(C)(C)C)C2)[C@H]1OCCN(c2ccc3c(c2)C(=O)N(C)C3)C1=O

HCID67222175

未命名化合物

收率 72.6%

PROCEDURE

实验过程

According to the Step 70-5 in the synthetic method for EXAMPLE 70, compound 70-4 (50 mg) was treated with tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (30 mg) to afford compound 72-1 (52 mg) as a light yellow solid after preparative LC purification.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fea3549c8c06443da1351811b3d7576f
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08987242B2
来源说明: uspto-grants-2015_03

反应 SMILES

[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[CH2:20][N:19]([CH3:24])[C:18]3=[O:25])[C:10]1=[O:26])[C:6](O)=[O:7])(=[O:3])[CH3:2].[NH2:27][C:28]1[CH:29]=[C:30]2[C:35](=[CH:36][CH:37]=1)[CH2:34][N:33]([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[CH2:32][CH2:31]2>>[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[CH2:20][N:19]([CH3:24])[C:18]3=[O:25])[C:10]1=[O:26])[C:6]([NH:27][C:28]1[CH:29]=[C:30]2[C:35](=[CH:36][CH:37]=1)[CH2:34][N:33]([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[CH2:32][CH2:31]2)=[O:7])(=[O:3])[CH3:2]