6-Amino-2-N-Boc-1,2,3,4-tetrahydro-isoquinoline → HCID 67222175, compound

HRID 876595Notes

Reaction equation

HRID 876595 reaction equation
[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[CH2:20][N:19]([CH3:24])[C:18]3=[O:25])[C:10]1=[O:26])[C:6](O)=[O:7])(=[O:3])[CH3:2].[NH2:27][C:28]1[CH:29]=[C:30]2[C:35](=[CH:36][CH:37]=1)[CH2:34][N:33]([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[CH2:32][CH2:31]2>>[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[CH2:20][N:19]([CH3:24])[C:18]3=[O:25])[C:10]1=[O:26])[C:6]([NH:27][C:28]1[CH:29]=[C:30]2[C:35](=[CH:36][CH:37]=1)[CH2:34][N:33]([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[CH2:32][CH2:31]2)=[O:7])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 27563716-Amino-2-N-Boc-1,2,3,4-tetrahydro-isoquinolineHCID 58181678HCID 58181678, compound

Product 1

HCID 67222175HCID 67222175, compoundYield 72.6%

Procedure

According to the Step 70-5 in the synthetic method for EXAMPLE 70, compound 70-4 (50 mg) was treated with tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (30 mg) to afford compound 72-1 (52 mg) as a light yellow solid after preparative LC purification.

Sources & evidence

ORD record
ord-fea3549c8c06443da1351811b3d7576f
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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