HRID876596

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21956239

5-Amino-2,3-dihydro-1H-isoindol-1-one

C8H8N2O

结构：CC(=O)O[C@@H](C(=O)O)[C@H]1OCCN(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O

HCID58181384

未命名化合物

PRODUCTS

生成物

结构：CC(=O)O[C@@H](C(=O)Nc1ccc2c(c1)CNC2=O)[C@H]1OCCN(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O

HCID58181829

未命名化合物

收率 81.5%

PROCEDURE

实验过程

According to the Step 70-5 in the synthetic method for EXAMPLE 70, compound 73-3 (65 mg) was used instead of compound 70-4 to couple to 5-aminoisoindolin-1-one (25 mg) to obtain compound 74-1 (69 mg) as a white solid after reverse-phase (C18) purification.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-996ee7fa4037479297e79bbc58f35ec1
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08987242B2
来源说明: uspto-grants-2015_03

反应 SMILES

[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([C:25]([F:28])([F:27])[F:26])[CH:16]=2)[C:10]1=[O:29])[C:6](O)=[O:7])(=[O:3])[CH3:2].[NH2:30][C:31]1[CH:32]=[C:33]2[C:37](=[CH:38][CH:39]=1)[C:36](=[O:40])[NH:35][CH2:34]2>>[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]([C:25]([F:26])([F:28])[F:27])[CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=2)[C:10]1=[O:29])[C:6](=[O:7])[NH:30][C:31]1[CH:32]=[C:33]2[C:37](=[CH:38][CH:39]=1)[C:36](=[O:40])[NH:35][CH2:34]2)(=[O:3])[CH3:2]