HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2,3-dihydro-isoindol-1-one → (R)-1-((R)-4-(3,5-bis(trifluoromethyl)phenyl)-3-oxomorpholin-2-yl)-2-oxo-2-(1-oxoisoindolin-5-ylamino)ethyl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2,3-dihydro-isoindol-1-one | HCID 21956239 | — |
| Reactant | HCID 58181384 | HCID 58181384 | — |
| Product | (R)-1-((R)-4-(3,5-bis(trifluoromethyl)phenyl)-3-oxomorpholin-2-yl)-2-oxo-2-(1-oxoisoindolin-5-ylamino)ethyl acetate | HCID 58181829 | 81.5% |
Reaction Steps
According to the Step 70-5 in the synthetic method for EXAMPLE 70, compound 73-3 (65 mg) was used instead of compound 70-4 to couple to 5-aminoisoindolin-1-one (25 mg) to obtain compound 74-1 (69 mg) as a white solid after reverse-phase (C18) purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987242B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-996ee7fa4037479297e79bbc58f35ec1 |
| Source note | uspto-grants-2015_03 |