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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 876609Generated: October 30, 2026

2-Thiopheneboronic acid → tert-butyl (2R)-2-hydroxy-2-[(2R)-4-[4-(2-methylsulfonylphenyl)phenyl]-3-oxomorpholin-2-yl]acetate

https://huagongshe.com/reaction/876609

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Thiopheneboronic acidHCID 2733960—
Reactant2-(Methylsulfonyl)phenylboronic AcidHCID 2773539—
ReactantHCID 67223457HCID 67223457—
Producttert-butyl (2R)-2-hydroxy-2-[(2R)-4-[4-(2-methylsulfonylphenyl)phenyl]-3-oxomorpholin-2-yl]acetateHCID 6722310779.8%

Reaction Steps

According to the Step 22-1 in synthetic method for EXAMPLE 22, compound 105-1 (0.12 g) and 2-methylsulfonylphenylboronic acid (0.11 g) were used instead of 14-4 and 2-thiopheneboronic acid to obtain compound 105-2 (102 mg) as yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08987242B2
Source datasetuspto-grants-2015_03
ORD IDord-3daefd2031134eb5a57deac97f37bff8
Source noteuspto-grants-2015_03