Sodium Hydroxide → HCID 67222070, compound

HRID 876613Notes

Reaction equation

HRID 876613 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)[C:6](=[O:17])[CH:5]1[CH:18]([OH:24])[C:19]([O:21]CC)=[O:20])(=[O:3])[CH3:2].O[Li:26].O.[OH-].[Na+]>>[Li+:26].[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:11]=[CH:12][C:13]([CH3:16])=[CH:14][CH:15]=2)[C:6](=[O:17])[CH:5]1[CH:18]([OH:24])[C:19]([O-:21])=[O:20])(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 168937Lithium hydroxide, monohydrateHCID 67222946HCID 67222946, compound

Product 1

HCID 67222070HCID 67222070, compoundYield 87.6%

Procedure

According to the Step 1-2 in synthetic method for EXAMPLE 1, compound 109-3 (0.11 g) and LiOH—H2O (13.8 mg) were used instead of 1-1 (LP) and NaOH to obtain compound 109-4 (90 mg) as a beige amorphous solid.

Sources & evidence

ORD record
ord-ddbd3f7f578e4ed0b85f041588b55eb4
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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