Sodium Hydroxide → HCID 87314935, compound

HRID 876614Notes

Reaction equation

HRID 876614 reaction equation
[CH:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=2)[C:5](=[O:16])[CH:4]1[CH:17]([OH:23])[C:18]([O:20]CC)=[O:19])=[O:2].O[Li:25].O.[OH-].[Na+]>>[Li+:25].[CH:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[CH:11][C:12]([CH3:15])=[CH:13][CH:14]=2)[C:5](=[O:16])[CH:4]1[CH:17]([OH:23])[C:18]([O-:20])=[O:19])=[O:2]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 168937Lithium hydroxide, monohydrateHCID 87314792HCID 87314792, compound

Product 1

HCID 87314935HCID 87314935, compoundYield 93.8%

Procedure

According to the Step 1-2 in synthetic method for EXAMPLE 1, compound 110-1 (0.14 g) and LiOH—H2O (18 mg) were used instead of 1-1 (LP) and NaOH to obtain compound 110-2 (0.12 g) as a colorless amorphous solid.

Sources & evidence

ORD record
ord-7ed2f8c6efee400a904a81473046725b
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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