Sodium Hydroxide → HCID 67222720, compound

HRID 876615Notes

Reaction equation

HRID 876615 reaction equation
[C:1]([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[C:11](=[O:22])[CH:10]1[CH:23]([OH:29])[C:24]([O:26]CC)=[O:25])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O[Li].O.[OH-].[Na+]>>[C:1]([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[C:11](=[O:22])[CH:10]1[CH:23]([OH:29])[C:24]([OH:26])=[O:25])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 168937Lithium hydroxide, monohydrateHCID 67221948HCID 67221948, compound

Product 1

HCID 67222720HCID 67222720, compoundYield 84.1%

Procedure

According to the Step 1-2 in synthetic method for EXAMPLE 1, compound 111-1 (128 mg) and LiOH—H2O (14.5 mg) were used instead of 1-1 (LP) and NaOH to obtain compound 111-2 (100 mg) as a beige amorphous solid.

Sources & evidence

ORD record
ord-1daa16eb109b447bb08e6a0736da3278
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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