4-Toluenesulfonyl chloride → HCID 67222160, compound

HRID 876620Notes

Reaction equation

Cl.[OH:2][CH:3]([CH:9]1[O:14][CH2:13][CH2:12][NH:11][CH2:10]1)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[S:15](Cl)([C:18]1[CH:24]=[CH:23][C:21]([CH3:22])=[CH:20][CH:19]=1)(=[O:17])=[O:16].S(Cl)(C)(=O)=O>>[OH:2][CH:3]([CH:9]1[O:14][CH2:13][CH2:12][N:11]([S:15]([C:18]2[CH:24]=[CH:23][C:21]([CH3:22])=[CH:20][CH:19]=2)(=[O:17])=[O:16])[CH2:10]1)[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

Reactant 3

HCID 73974-Toluenesulfonyl chloride

HCID 31297Methanesulfonyl chloride

HCID 67222241HCID 67222241, compound

Product 1

HCID 67222160HCID 67222160, compoundYield 35.5%

Procedure

According to the Step 28-1 in synthetic method for EXAMPLE 28, compound 115-3 (0.2 g) and tosylchloride (203 mg) were used instead of 26-5 and mesyl chloride to obtain compound 116-1 (108 mg) as a pale yellow amorphous solid.

Sources & evidence

ORD record: ord-6727d85f4a1f4eaaa9bea6d9b5db1434
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08987242B2

Reaction notes

Loading…