3-Iodobenzoic acid → HCID 136337793, compound

HRID 876621Notes

Reaction equation

HRID 876621 reaction equation
[OH:1][CH:2]([CH:6]1[O:11][CH2:10][CH2:9][N:8]([S:12]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)(=[O:14])=[O:13])[CH2:7]1)[C:3]([OH:5])=O.[NH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[NH:30][O:31][C:32](=[O:34])[N:33]=2)=[CH:25][CH:24]=1.IC1C=C(C=CC=1)C(O)=O.FC1(F)CCNCC1>>[OH:1][CH:2]([CH:6]1[O:11][CH2:10][CH2:9][N:8]([S:12]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)(=[O:14])=[O:13])[CH2:7]1)[C:3]([NH:22][C:23]1[CH:24]=[CH:25][C:26]([C:29]2[NH:33][C:32](=[O:34])[O:31][N:30]=2)=[CH:27][CH:28]=1)=[O:5]

Participants

5

Reactant 4

HCID 120603-Iodobenzoic acidHCID 27583524,4-DifluoropiperidineHCID 67222792HCID 67222792, compoundHCID 178507458HCID 178507458, compound

Product 1

HCID 136337793HCID 136337793, compoundYield 58.7%

Procedure

According to the Step 77-1 in synthetic method for EXAMPLE 77, compound 116-2 (94 mg) and 3-(4-aminophenyl)-1,2,4-oxadiazol-5(2H)-one (79.2 mg) were used instead of 3-iodobenzoic acid and 4,4-difluoropiperidine to obtain compound 116-3 (83 mg) as a pale yellow amorphous solid.

Sources & evidence

ORD record
ord-1c986cbfb749497abde96fc05a446243
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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