Sodium Hydroxide → HCID 67221720, compound

HRID 876622Notes

Reaction equation

HRID 876622 reaction equation
[OH:1][CH:2]([CH:8]1[O:13][CH2:12][CH2:11][N:10]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[CH2:9]1)[C:3]([O:5]CC)=[O:4].O[Li:22].O.[OH-].[Na+]>>[Li+:22].[OH:1][CH:2]([CH:8]1[O:13][CH2:12][CH2:11][N:10]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[CH2:9]1)[C:3]([O-:5])=[O:4]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 168937Lithium hydroxide, monohydrateHCID 67222697HCID 67222697, compound

Product 1

HCID 67221720HCID 67221720, compoundYield 98.9%

Procedure

According to the Step 1-2 in synthetic method for EXAMPLE 1, compound 117-1 (45 mg) and LiOH—H2O (6.8 mg) were used instead of 1-1 (LP) and NaOH to obtain compound 117-2 (41 mg) as a pale yellow amorphous solid.

Sources & evidence

ORD record
ord-a5441fb47d2a497dacd3e46a56fc681b
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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