Methyl iodide → HCID 67034282, compound

HRID 876626Notes

Reaction equation

HRID 876626 reaction equation
[I:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[CH:13]1([CH2:16]Br)[CH2:15][CH2:14]1.CI>>[CH:13]1([CH2:16][N:9]2[C:10]3[C:5](=[CH:4][CH:3]=[C:2]([I:1])[CH:11]=3)[CH2:6][CH2:7][C:8]2=[O:12])[CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 81503BromomethylcyclopropaneHCID 588514003,4-Dihydro-7-iodo-2(1H)-quinolinone

Product 1

HCID 67034282HCID 67034282, compound

Procedure

According to the Step 8-1 in synthetic method for EXAMPLE aa8, 3,4-dihydro-7-iodo-2(1H)-quinolinone (1.50 g) and cyclopropylmethyl bromide (0.80 mL) were used instead of a7-1 and MeI to obtain compound aa20-1 (1.23 g) as a pale red amorphous solid.

Workup

  1. customto obtain compound aa20-1 (1.23 g) as a pale red amorphous solid

Sources & evidence

ORD record
ord-572407efabd940bcbf99af7ff6b8fafb
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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