Methyl iodide → HCID 67032868, compound

HRID 876627Notes

Reaction equation

HRID 876627 reaction equation
[I:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[CH3:13][O:14][C:15](=[O:18])[CH2:16]Br.CI>>[I:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[N:9]2[CH2:16][C:15]([O:14][CH3:13])=[O:18])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 60984Methyl bromoacetateHCID 588514003,4-Dihydro-7-iodo-2(1H)-quinolinone

Product 1

HCID 67032868HCID 67032868, compound

Procedure

According to the Step 8-1 in synthetic method for EXAMPLE aa8, 3,4-dihydro-7-iodo-2(1H)-quinolinone (2.12 g) and bromoacetic acid methyl ester (1.10 mL) were used instead of aa7-1 and MeI to obtain compound aa21-1 (2.24 g) as a white amorphous solid.

Workup

  1. customto obtain compound aa21-1 (2.24 g) as a white amorphous solid

Sources & evidence

ORD record
ord-1a293eb2720644198dc007a49d9d0a66
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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