N-bromobutanimide → HCID 58290597, compound

HRID 876635Notes

Reaction equation

HRID 876635 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1)[NH2:5].C1C(=O)N([Br:20])C(=O)C1>C(Cl)Cl>[Br:20][C:8]1[C:7]([C:9]([F:10])([F:11])[F:12])=[CH:6][C:4]([NH2:5])=[CH:3][C:2]=1[CH3:1]

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 27377133-Amino-5-methylbenzotrifluoride

Product 1

HCID 58290597HCID 58290597, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

3-methyl-5-(trifluoromethyl)aniline (4.84 g, 0.011 mol) was dissolved in CH2Cl2 and cooled to 0° C. NBS (4.92 g, 1 eq) was added and the mixture stirred overnight. The reaction mixture was loaded onto silica gel and eluted with 0-20% EtOAc in hexane to give 2.3 g of M21-1.

Workup

  1. washeluted with 0-20% EtOAc in hexane
  2. customto give 2.3 g of M21-1

Sources & evidence

ORD record
ord-7f2428c7e38144a08fcf485fcc641492
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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