反应详情

118.2 g (5.1 mol) sodium are slowly added to 2.5 liters ethanol. 350.0 g (5.1 mol) imidazole are then added and 570 ml (858.6 g, 5.1 mol) ethyl bromoacetate are added dropwise at an internal temperature of 20-25° C. The mixture is stirred at RT for 24 h. The solid which has precipitated out is filtered off, the ethanol is removed in vacuo and the mixture is filtered again. The residue is purified by column chromatography over silica gel (mobile phase: ethyl acetate).

1. customThe solid which has precipitated out
2. filtrationis filtered off
3. customthe ethanol is removed in vacuo
4. filtrationthe mixture is filtered again
5. customThe residue is purified by column chromatography over silica gel (mobile phase: ethyl acetate)