HCID 24812791, compound → HCID 68752833, compound

HRID 876694Notes

Reaction equation

HRID 876694 reaction equation
[ClH:1].C([O:6][C:7]([C:9]1[CH:10]=[N:11][C:12]([N:15]2[C:19](=[O:20])[C:18]([N:21]3[CH:25]=[CH:24][N:23]=[N:22]3)=[CH:17][NH:16]2)=[CH:13][CH:14]=1)=[O:8])(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[ClH:1].[O:20]=[C:19]1[N:15]([C:12]2[N:11]=[CH:10][C:9]([C:7]([OH:8])=[O:6])=[CH:14][CH:13]=2)[NH:16][CH:17]=[C:18]1[N:21]1[CH:25]=[CH:24][N:23]=[N:22]1

Participants

4

Reactant 1

HCID 24812791HCID 24812791, compound

Product 1

HCID 68752833HCID 68752833, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

50 mg (0.1 mmol) of the compound from Example 62 are dissolved in 1 ml of a 1:1 mixture of methylene chloride and TFA and the mixture is stirred at RT for 1 h. The reaction solution is concentrated in vacuo, the residue is suspended in 2 ml 1 N hydrochloric acid and the suspension is then lyophilized.

Workup

  1. concentrationThe reaction solution is concentrated in vacuo

Sources & evidence

ORD record
ord-e25632c0731d405982cf25a35c9dcac7
Source dataset
uspto-grants-2015_03
Patent number
US08987261B2

Reaction notes

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