Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (6-Morpholin-4-ylpyrimidin-4-yl)hydrazine | HCID 13393622 | — |
| Reactant | Ethyl 3-(dimethylamino)-2-(1H-1,2,3-triazol-1-yl)acrylate | HCID 66726233 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Molidustat | HCID 59603622 | 61.5% |
Reaction Steps
1.9 g (8.8 mmol) of the compound from Example 3A and 1.9 g (9.7 mmol) of the compound from Example 16A are initially introduced into 25 ml ethyl acetate and 504 mg (4.4 mmol) TFA are added at RT. The mixture is stirred under reflux for 16 h, then cooled to 5° C. and subsequently stirred for a further 2 h. The solid formed is filtered off, washed with ethyl acetate and dried first in air and thereafter under a high vacuum. 1.7 g of product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08987261B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-0dd197c44bda4080938e92af406ba908 |
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| Source note | uspto-grants-2015_03 |
|---|
