反应详情

温度

5 °C

1.9 g (8.8 mmol) of the compound from Example 3A and 1.9 g (9.7 mmol) of the compound from Example 16A are initially introduced into 25 ml ethyl acetate and 504 mg (4.4 mmol) TFA are added at RT. The mixture is stirred under reflux for 16 h, then cooled to 5° C. and subsequently stirred for a further 2 h. The solid formed is filtered off, washed with ethyl acetate and dried first in air and thereafter under a high vacuum. 1.7 g of product are obtained.

1. additionare added at RT
2. temperatureunder reflux for 16 h
3. stirringsubsequently stirred for a further 2 h
4. customThe solid formed
5. filtrationis filtered off
6. washwashed with ethyl acetate
7. customdried first in air