Hydrochloric Acid → 2-[5-(2,2-Dimethylpropoxy)pyridin-2-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one hydrochloride

HRID 876701Notes

Reaction equation

HRID 876701 reaction equation
[ClH:1].[CH3:2][C:3]([CH3:24])([CH3:23])[CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([N:12]2[C:16](=[O:17])[C:15]([N:18]3[CH:22]=[CH:21][N:20]=[N:19]3)=[CH:14][NH:13]2)=[N:10][CH:11]=1>O1CCOCC1>[ClH:1].[CH3:2][C:3]([CH3:24])([CH3:23])[CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([N:12]2[C:16](=[O:17])[C:15]([N:18]3[CH:22]=[CH:21][N:20]=[N:19]3)=[CH:14][NH:13]2)=[N:10][CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 596035532-[5-(2,2-Dimethylpropoxy)pyridin-2-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one

Product 1

HCID 674577372-[5-(2,2-Dimethylpropoxy)pyridin-2-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2 ml of a 4 N solution of hydrogen chloride in dioxane are added to 22 mg (0.1 mmol) of the compound from Example 84 and the mixture is stirred at RT for 1 h. The solid is filtered off and dried under a high vacuum.

Workup

  1. filtrationThe solid is filtered off
  2. customdried under a high vacuum

Sources & evidence

ORD record
ord-3a474cf4c0064ef6b2e3b17826c1823d
Source dataset
uspto-grants-2015_03
Patent number
US08987261B2

Reaction notes

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