Hydrochloric Acid → HCID 67455384, compound

HRID 876702Notes

Reaction equation

HRID 876702 reaction equation
[ClH:1].FC(F)(F)C(O)=O.[N:9]1([C:15]2[N:20]=[CH:19][N:18]=[C:17]([N:21]3[C:25](=[O:26])[C:24]([N:27]4[CH:31]=[C:30]([C:32]#[N:33])[N:29]=[N:28]4)=[CH:23][NH:22]3)[CH:16]=2)[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>O1CCOCC1>[ClH:1].[N:9]1([C:15]2[N:20]=[CH:19][N:18]=[C:17]([N:21]3[C:25](=[O:26])[C:24]([N:27]4[CH:31]=[C:30]([C:32]#[N:33])[N:29]=[N:28]4)=[CH:23][NH:22]3)[CH:16]=2)[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67456714HCID 67456714, compound

Product 1

HCID 67455384HCID 67455384, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3 ml of a 4 N solution of hydrogen chloride in dioxane are added to 18 mg (0.04 mmol) of the compound from Example 86 and the mixture is stirred at RT for 1 h. The solid is filtered off, washed with tert-butyl methyl ether and dried under a high vacuum.

Workup

  1. filtrationThe solid is filtered off
  2. washwashed with tert-butyl methyl ether
  3. customdried under a high vacuum

Sources & evidence

ORD record
ord-648edb16c1504d71836e9439d03c63ce
Source dataset
uspto-grants-2015_03
Patent number
US08987261B2

Reaction notes

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