反应详情

To a solution of methyl chlorooxoacetate in TBME (1 mmol/ml) was added at 0-5° C. tert-butanol (1.5 equiv.), followed by dropwise addition of pyridine (1.5 equiv.). The resulting mixture was stirred at room temperature for 20 h. Water (15 vol.) was added, the mixture was extracted with TBME twice. The combined organic extracts were washed with brine, dried over anhydrous Na2SO4 and concentrated under vacuum to give a colorless oil.

1. extractionthe mixture was extracted with TBME twice
2. washThe combined organic extracts were washed with brine
3. dry with materialdried over anhydrous Na2SO4
4. concentrationconcentrated under vacuum
5. customto give a colorless oil