Aluminium lithium hydride → 1-(Thieno[3,2-c]pyridin-2-yl)ethan-1-ol

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Reaction Steps

To a solution of 1-(thieno[3,2-c]pyridin-2-yl) ethanone (D′-3) (3.5 g, 1 mmol) in anhydrous THF (50 mL) was added LiAlH4 (1.13 g, 1.5 mmol) in portions at 0° C. The suspension was stirred under this temperature for 1 h. The reaction mixture was quenched with saturated aqueous NH4Cl solution and filtered. The filtrate was washed with brine, concentrated, and then used for the next step without any further purification.

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