反应详情

To a solution of 1-(thieno[3,2-c]pyridin-2-yl) ethanone (D′-3) (3.5 g, 1 mmol) in anhydrous THF (50 mL) was added LiAlH4 (1.13 g, 1.5 mmol) in portions at 0° C. The suspension was stirred under this temperature for 1 h. The reaction mixture was quenched with saturated aqueous NH4Cl solution and filtered. The filtrate was washed with brine, concentrated, and then used for the next step without any further purification.

1. customThe reaction mixture was quenched with saturated aqueous NH4Cl solution
2. filtrationfiltered
3. washThe filtrate was washed with brine
4. concentrationconcentrated
5. customused for the next step without any further purification