Hydrochloric Acid → HCID 56644775, compound

Participants

Reaction Steps

100 mg (0.22 mmol) {1-[4-(2-Methyl-7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester, (intermediate example int-2-2), were stirred with 7.5 mL 4M hydrogen chloride in dioxane over night at room temperature. After evaporation of the solvent the residue was treated with a mixture of methyl-tert. butylether and dichloromethane (1:1) and stirred over night at room temperature. The precipitate was filtered off yielding 132 mg (76%) of the title compound.

Provenance & Evidence