Hydrochloric Acid → HCID 56644775, compound

HRID 876872Notes

Reaction equation

HRID 876872 reaction equation
C(OC(=O)[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:19]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[CH:20][C:21]4[N:22]([CH:24]=[C:25]([CH3:27])[N:26]=4)[N:23]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)(C)(C)C.[ClH:35]>O1CCOCC1>[ClH:35].[CH3:27][C:25]1[N:26]=[C:21]2[CH:20]=[C:19]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:18]([C:15]3[CH:16]=[CH:17][C:12]([C:8]4([NH2:7])[CH2:11][CH2:10][CH2:9]4)=[CH:13][CH:14]=3)=[N:23][N:22]2[CH:24]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66714385HCID 66714385, compound

Product 1

HCID 56644775HCID 56644775, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

100 mg (0.22 mmol) {1-[4-(2-Methyl-7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester, (intermediate example int-2-2), were stirred with 7.5 mL 4M hydrogen chloride in dioxane over night at room temperature. After evaporation of the solvent the residue was treated with a mixture of methyl-tert. butylether and dichloromethane (1:1) and stirred over night at room temperature. The precipitate was filtered off yielding 132 mg (76%) of the title compound.

Workup

  1. customAfter evaporation of the solvent the residue
  2. additionwas treated with a mixture of methyl-tert. butylether and dichloromethane (1:1)
  3. filtrationThe precipitate was filtered off

Sources & evidence

ORD record
ord-cf284b22c6ae4bdfa284eb6707ae15be
Source dataset
uspto-grants-2015_03
Patent number
US08987273B2

Reaction notes

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