HCID 86692123, compound → HCID 56645598, compound

HRID 876886Notes

Reaction equation

HRID 876886 reaction equation
C(OC(=O)[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:19]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)=[CH:20][C:21]4[N:22]([C:24]([CH:28]=[CH2:29])=[C:25]([CH3:27])[N:26]=4)[N:23]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)(C)(C)C>Cl.O1CCOCC1>[CH3:27][C:25]1[N:26]=[C:21]2[CH:20]=[C:19]([C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)[C:18]([C:15]3[CH:16]=[CH:17][C:12]([C:8]4([NH2:7])[CH2:11][CH2:10][CH2:9]4)=[CH:13][CH:14]=3)=[N:23][N:22]2[C:24]=1[CH:28]=[CH2:29]

Participants

4

Reactant 1

HCID 86692123HCID 86692123, compound

Product 1

HCID 56645598HCID 56645598, compoundYield 18.3%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

244 mg Of the crude {1-[4-(2-methyl-7-phenyl-3-vinyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester were stirred in 16.1 mL 4M hydrogen chloride in dioxane for 22 hours at room temperature. The reaction mixture was worked up as described in the previous example. The crude product (178 mg) was purified by HPLC to yield 35.3 mg of the title compound.

Workup

  1. customThe crude product (178 mg) was purified by HPLC

Sources & evidence

ORD record
ord-8972ebdcbeeb4d8d9ba3a550dffc4e27
Source dataset
uspto-grants-2015_03
Patent number
US08987273B2

Reaction notes

Loading…