2,2,2-Trifluoroethanol → 7-(5-Methylfuran-2-yl)-3-(6-[2,2,2-trifluoroethyl]oxymethylpyrid-2-ylmethyl)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine

HRID 876999Notes

Reaction equation

HRID 876999 reaction equation
Br[CH2:2][C:3]1[N:8]=[C:7]([CH2:9][N:10]2[C:14]3[N:15]=[C:16]([NH2:25])[N:17]=[C:18]([C:19]4[O:20][C:21]([CH3:24])=[CH:22][CH:23]=4)[C:13]=3[N:12]=[N:11]2)[CH:6]=[CH:5][CH:4]=1.[CH2:26]([OH:31])[C:27]([F:30])([F:29])[F:28]>>[CH3:24][C:21]1[O:20][C:19]([C:18]2[C:13]3[N:12]=[N:11][N:10]([CH2:9][C:7]4[CH:6]=[CH:5][CH:4]=[C:3]([CH2:2][O:31][CH2:26][C:27]([F:30])([F:29])[F:28])[N:8]=4)[C:14]=3[N:15]=[C:16]([NH2:25])[N:17]=2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 667183513-(6-Bromomethylpyridin-2-ylmethyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine

Product 1

HCID 445553197-(5-Methylfuran-2-yl)-3-(6-[2,2,2-trifluoroethyl]oxymethylpyrid-2-ylmethyl)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine

Procedure

Prepared from 3-(6-bromomethylpyridin-2-ylmethyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine and trifluoroethanol by the method described in Example 32.

Sources & evidence

ORD record
ord-b6593d8f4b5845c8b1da5c0ed204704a
Source dataset
uspto-grants-2015_03
Patent number
US08987279B2

Reaction notes

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