HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → 6-Iodoquinazolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Benzoic acid, 2-amino-5-iodo- | HCID 72911 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Iodoquinazolin-4-one | HCID 135401666 | 81% |
Reaction Steps
A solution of 2-amino-5-iodobenzoic acid (14.2 g, 50 mmol) and formamide (100 mL) was refluxed for 10 hours. After cooling to room temperature, water (100 mL) was added. The solid product was collected by filtration, washed with water. Further drying in a vacuum provided 6-Iodo-4-quinazolinone (11 g, 81%) as a gray solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987284B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-cc4553807c0e4c1fa41981a6e7ced10b |
| Source note | uspto-grants-2015_03 |