反应详情

To a solution of 6-Iodo-quinazolin-4-ol (5.0 g, 18 mmol) in thionyl chloride (10 mL) was added slowly DMF (0.5 mL) and the mixture is heated immediately to reflux. Heating is continued for 4.5 hours, followed by cooling to room temperature. The reaction mixture was then evaporated under reduced pressure to dryness. The residue was then redesolved in DCM (20 mL), and to it was added toluene (50 mL), and the mixture was then evaporated under reduced pressure to dryness. The procedure was repeated one more time to rid the product of thionyl chloride to yield 5.2 g (99%) of desired product as a tan solid.

1. temperaturethe mixture is heated immediately
2. temperatureto reflux
3. temperatureHeating
4. customThe reaction mixture was then evaporated under reduced pressure to dryness
5. additionto it was added toluene (50 mL)
6. customthe mixture was then evaporated under reduced pressure to dryness