HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 877086Generated: October 30, 2026
Potassium Carbonate → 5-(4-(3-Chloro-4-(pyridin-2-ylmethoxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde
https://huagongshe.com/reaction/877086
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Furan-2-boronic acid | HCID 2734357 | — |
| Reactant | [3-Chloro-4-(2-pyridylmethoxyl)-phenyl]-(6-iodo-quinazolin-4-yl)-amine hydrochloride salt | HCID 68153209 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 5-(4-(3-Chloro-4-(pyridin-2-ylmethoxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde | HCID 87424904 | — |
Reaction Steps
A mixture of compound 8.3 (489 mg, 1.0 mmol), 2-furylboronic acid (185 mg, 1.2 mmol) and palladium catalyst (73.0 mg, 0.10 mmol) in 1.0 mL of K2CO3 (2.0M), 1.0 mL of EtOH and 4.0 mL of DME was heated at 75° C. under nitrogen atmosphere for 4 hr. LS-MS showed the reaction completed. Concentrated the mixture under reduced pressure and washed the residue with water (2×5.0 mL) then with cool ether (10.0 mL) to get a gray solid (400 mg), which was used for next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08987284B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-ae9d60f09a4f4ad2a023ef63d479a528 |
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| Source note | uspto-grants-2015_03 |
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