Potassium Carbonate → 5-(4-(3-Chloro-4-(pyridin-2-ylmethoxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

HRID 877086Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:4]=[C:5]([NH:17][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25](I)[CH:26]=3)[N:21]=[CH:20][N:19]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1.[O:29]1[CH:33]=[CH:32][CH:31]=[C:30]1B(O)O.[C:37]([O-])([O-])=[O:38].[K+].[K+]>[Pd].CCO.COCCOC>[Cl:2][C:3]1[CH:4]=[C:5]([NH:17][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([C:33]4[O:29][C:30]([CH:37]=[O:38])=[CH:31][CH:32]=4)[CH:26]=3)[N:21]=[CH:20][N:19]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1

Participants

Conditions

Temperature: 75 °C

Procedure

A mixture of compound 8.3 (489 mg, 1.0 mmol), 2-furylboronic acid (185 mg, 1.2 mmol) and palladium catalyst (73.0 mg, 0.10 mmol) in 1.0 mL of K2CO3 (2.0M), 1.0 mL of EtOH and 4.0 mL of DME was heated at 75° C. under nitrogen atmosphere for 4 hr. LS-MS showed the reaction completed. Concentrated the mixture under reduced pressure and washed the residue with water (2×5.0 mL) then with cool ether (10.0 mL) to get a gray solid (400 mg), which was used for next step without further purification.

Workup

concentrationConcentrated the mixture under reduced pressure
washwashed the residue with water (2×5.0 mL)

Sources & evidence

ORD record: ord-ae9d60f09a4f4ad2a023ef63d479a528
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08987284B2

Reaction notes

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