HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → 2-Bromo-1-(3-fluorobenzyloxy)-4-nitrobenzene
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 3-Fluorobenzylic alcohol | HCID 68008 | — |
| Edukt | 2-Bromo-1-fluoro-4-nitrobenzene | HCID 69699 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Produkt | 2-Bromo-1-(3-fluorobenzyloxy)-4-nitrobenzene | HCID 21874800 | 92% |
Reaktionsschritte
The mixture of 2-bromo-1-fluoro-4-nitrobenzene (5 g), (3-fluorophenyl)methanol (2.86 g) and K2CO3 (9.4 g) in Acetone (50 mL) was refluxed for 4 h. The solid was filtered and the solvent was removed. The obtained yellow solid was recrystallized from EtOAc/Hexane to provide brown solid (6.8 g). Yield: 92%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08987284B2 |
| Quelldatensatz | uspto-grants-2015_03 |
| ORD ID | ord-148cea4396cb4492aacbada4a9725cb3 |
| Quellennotiz | uspto-grants-2015_03 |