4-Chloro-6-iodoquinazoline → HCID 67504459, compound

HRID 877109Notes

Reaction equation

HRID 877109 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][C:8]=1[C:14]#[C:15][Si:16]([CH:23]([CH3:25])[CH3:24])([CH:20]([CH3:22])[CH3:21])[CH:17]([CH3:19])[CH3:18].Cl[C:30]1[C:39]2[C:34](=[CH:35][CH:36]=[C:37]([I:40])[CH:38]=2)[N:33]=[CH:32][N:31]=1>C(O)(C)C>[F:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:30]2[C:39]3[C:34](=[CH:35][CH:36]=[C:37]([I:40])[CH:38]=3)[N:33]=[CH:32][N:31]=2)=[CH:9][C:8]=1[C:14]#[C:15][Si:16]([CH:17]([CH3:18])[CH3:19])([CH:20]([CH3:21])[CH3:22])[CH:23]([CH3:25])[CH3:24]

Participants

4

Reactant 2

HCID 111738094-Chloro-6-iodoquinazolineHCID 675042324-(3-Fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)benzenamine

Product 1

HCID 67504459HCID 67504459, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)benzenamine (900 mg, 2.27 mmol) and 4-chloro-6-iodo-quinazoline (657 mg, 2.27 mmol) were dissolved in isopropanol (50 ml). The reaction mixture was refluxed for 12 hours. The solid product was collected by filtration, washed with cold isopropanol (10 mL) and ether (20 mL), and air dried to afford the clean desired material.

Workup

  1. temperatureThe reaction mixture was refluxed for 12 hours
  2. filtrationThe solid product was collected by filtration
  3. washwashed with cold isopropanol (10 mL) and ether (20 mL), and air
  4. customdried

Sources & evidence

ORD record
ord-0763fb2f869f48f5a2b0276b88f3d500
Source dataset
uspto-grants-2015_03
Patent number
US08987284B2

Reaction notes

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