反应详情

温度

75 °C

Under nitrogen atmosphere, Pd(dppf)2Cl2 (48 mg) was added to a mixture of N-(4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)phenyl)-6-iodoquinazolin-4-amine (420 mg, 0.65 mmole), 5-formylfuran-2-yl-2-boronic acid (108 mg, 1.2 equiv.) and 2M K2CO3 (4 mL) in Ethanol (4 mL) and DME (4 mL). The reaction mixture was heated at 75° C. for 4 h and cooled down to room temperature. Methylene chloride (30 mL) was added and washed with water and brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was purified by flash chromatography, eluting with 20% methanol in dichloromethane to give the desired product as white solid (300 mg). LCMS ESI(+) m/z: 620 (M+1). Yield: 75%.

1. temperaturecooled down to room temperature
2. washwashed with water and brine
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was purified by flash chromatography
7. washeluting with 20% methanol in dichloromethane