Methanol → HCID 66893992, compound

HRID 877172Notes

Reaction equation

HRID 877172 reaction equation
S(Cl)([Cl:3])=O.[NH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH:8]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])[CH2:7]1.[CH3:17]O>>[ClH:3].[NH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH:8]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:7]1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 4523697HCID 4523697, compound

Product 1

HCID 66893992HCID 66893992, compound

Procedure

At −5° C., 1.9 ml (25.7 mmol) of thionyl chloride were slowly added dropwise to 50 ml of methanol, and the mixture was stirred at this temperature for 10 min. 2 g (11.7 mmol) of 3-(3-aminocyclohexyl)propanoic acid were then added in one portion, and the reaction mixture was stirred at room temperature overnight. After the reaction had gone to completion, the solvent was evaporated under reduced pressure. This gave 2.46 g (11.1 mmol, 95% of theory) of a colorless solid.

Workup

  1. stirringthe reaction mixture was stirred at room temperature overnight
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-3478c03fd6ab48f4887030b5cfc5ba15
Source dataset
uspto-grants-2015_03
Patent number
US08987256B2

Reaction notes

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