Methanol → HCID 66893992, compound

Participants

Reaction Steps

At −5° C., 1.9 ml (25.7 mmol) of thionyl chloride were slowly added dropwise to 50 ml of methanol, and the mixture was stirred at this temperature for 10 min. 2 g (11.7 mmol) of 3-(3-aminocyclohexyl)propanoic acid were then added in one portion, and the reaction mixture was stirred at room temperature overnight. After the reaction had gone to completion, the solvent was evaporated under reduced pressure. This gave 2.46 g (11.1 mmol, 95% of theory) of a colorless solid.

Provenance & Evidence