Hydrochloric Acid → HCID 66895260, compound

HRID 877175Notes

Reaction equation

HRID 877175 reaction equation
[CH3:1][C:2]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-])=O)[C:10]=1[CH3:18])([CH3:7])[C:3]([O:5][CH3:6])=[O:4].[ClH:19]>C(O)C.[Pd]>[ClH:19].[NH2:15][C:11]1[C:10]([CH3:18])=[C:9]([CH:14]=[CH:13][CH:12]=1)[O:8][C:2]([CH3:7])([CH3:1])[C:3]([O:5][CH3:6])=[O:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58136580HCID 58136580, compound

Product 1

HCID 66895260HCID 66895260, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1.33 g (5.25 mmol) of methyl 2-methyl-2-(2-methyl-3-nitrophenoxy)propanoate were dissolved in 60 ml of ethanol, and 1 ml of concentrated hydrochloric acid and 0.30 g of palladium on carbon (10%) were added. Under an atmosphere of hydrogen, the mixture was hydrogenated at atmospheric pressure and room temperature for 3 h. The reaction mixture was then filtered through Tonsil. The filter residue was washed with ethanol and the collected filtrates were concentrated under reduced pressure. This gave 1.39 g (89% of theory) of the target compound.

Workup

  1. filtrationThe reaction mixture was then filtered through Tonsil
  2. washThe filter residue was washed with ethanol
  3. concentrationthe collected filtrates were concentrated under reduced pressure

Sources & evidence

ORD record
ord-7d2ad7f8aa214f1eb8b9924c74b40288
Source dataset
uspto-grants-2015_03
Patent number
US08987256B2

Reaction notes

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